Please use this identifier to cite or link to this item: http://cuir.car.chula.ac.th/handle/123456789/14340
Title: Long-term oral vitamin C administration improves cerebral microvascular vasodilatory impairment in diabetes: in vivo evidence using diabetic rats
Authors: Amporn Jariyapongskul
Yamaguchi, Saburo
Suthiluk Patumraj
Email: No information provided
No Information Provided
Suthiluk.P@Chula.ac.th
Other author: Srinakharinvirot University. Faculty of Medicine
National Cardiovascular Center Research Institute. Department of Vascular Physiology
Chulalongkorn University. Faculty of Medicine
Subjects: Diabetes
vitamin C
Issue Date: 2007
Publisher: Chulalongkorn University
Citation: Asian biomedicine : research, reviews and news. 1,2(August 2007) : 159-166
Abstract: Objective: To investigate long-term effects of oral vitamin C administration on the cerebral microvascular vasodilation in diabetes, using streptozotocin (STZ)-induced diabetic rats. Materials and methods: Diabetes was induced in male Wistar Furth rats by a single intravenous injection of STZ (55 mg/kg b.w). Ascorbic acid (vitamin C) was administered in drinking water (1g/l). The rats were divided into control and diabetic groups with or without administration of vitamin C. The cerebral microcirculation was observed at different times (12, 24 and 36 weeks) after vitamin C supplementation, using fluorescence videomicroscopy. Responses of cerebral arterioles to acetylcholine (ACh), adenosine-5 diphosphate (ADP) and nitroglycerine (NTG) were studied by measuring diameters of cerebral arterioles before and after topical application on the cortical surface. Results: The vasodilatory responses of cerebral arterioles to ACh and ADP were significantly decreased in diabetic rats, compared with non-diabetic (control) rats. The response to NTG was not altered in diabetic rats, indicating that the vasodilatory impairment involves at the endothelium. The impaired endothelium-dependent vasodilation was prevented by long-term vitamin C administration.
URI: http://cuir.car.chula.ac.th/handle/123456789/14340
ISSN: 1905-7415
Type: Article
Appears in Collections:Med - Journal Articles

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