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Title: การศึกษาชีวสมมูลของยาคุมกำเนิดหลังร่วมเพศ (ลีโวนอร์เจสเตรล 0.75 มิลลิกรัม) สองชนิดในสตรีไทย
Other Titles: The bioequivalence study of two postcoital contraceptives (levonorgestrel 0.75 mg.) in Thai women
Authors: อรวรรณ กิจควร
Advisors: สุมนา ชมพูทวีป
สมัย ลีพัฒน์ไพบูลย์
Other author: จุฬาลงกรณ์มหาวิทยาลัย. บัณฑิตวิทยาลัย
Issue Date: 2543
Publisher: จุฬาลงกรณ์มหาวิทยาลัย
Other Abstract: The purpose of this study was to determine the bioequivalence of two postcoital contraceptives containing levonorgestrel 0.75 mg which were local and original product. The experiment was assigned to be randomized crossover design in 12 healthy Thai female volunteers who were given a single oral dose of levonorgestrel 0.75 mg (1 tablet) and blood samples were drawn at O, 1, 1.5, 2, 2.5 3, 3.5, 4, 6, 10 and 24 hrs after drug administration. The plasma drug concentration was determine by radioimmunoassay and analyzed for pharmacokinetic parameters of levonorgestrel. The results present that the peak plasma concentration (C[subscript max]), the time to peak plasma concentration (t[subscript max]) and area under the plasma concentration time curve (AUC) between two product were statistically difference (p<0.05). Difference of t[subscript max] equals 55.08% and the 90% Confidence interval for the difference of C[subscript max] and AUC means based on log transformed data of two products were within 9.24-124.29% and 65.13-105.67% respectively, referring, the two postcoital contraceptives were not bioequivalence.
Description: วิทยานิพนธ์ (วท.ม.)--จุฬาลงกรณ์มหาวิทยาลัย, 2543
Degree Name: วิทยาศาสตรมหาบัณฑิต
Degree Level: ปริญญาโท
Degree Discipline: เภสัชวิทยา (สหสาขาวิชา)
ISBN: 9743348913
Type: Thesis
Appears in Collections:Grad - Theses

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