Study of the platelet rich fibrin in alveolar cleft bone graft by using cone beam computed tomography

Abstract

Objective To compare the healing of the PRF-combined bone graft in alveolar cleft with the non-PRF-combined group Materials and methods Thirteen cleft lip and palate patients with 15 alveolar clefts scheduled for iliac cancellous bone graft were classified into 2 groups. PRF group consisted of 8 cleft sites which PRF was added. Non-PRF group was 7 cleft sites grafted without PRF. CBCT was performed before surgery and 6 months after surgery. Periapical radiograph was evaluated before surgery, 1, 3 and 6 months after surgery. The volume percentage and relative density of filled bone were analyzed by Mann-Whitney U test and Friedman test (p-value < .05). Moreover, the position of filled bone was classified by Chelsea scale. Results From CBCT, there was no statistical difference of the volume percentage and relative density change at the 6th month post-operation between 2 groups (p = 0.817 and 0.908, respectively). From periapical radiographs, the relative density of filled bone at the 1st, 3rd and 6th month displayed no statistical difference between 2 groups (p = 0.775, 0.570 and 0.949, respectively). Relative density change in the PRF group increased more than those of the non-PRF group at the 3rd month post-operation (0.175 ± 0.21 and 0.239 ± 0.14, respectively) and at the 6th month post-operation (0.034 ± 0.27 and 0.090 ± 0.36, respectively). However, no statistical difference was found between both groups (p = 0.173 and 0.465, at the 3rd and 6th month respectively). The position of filled bone, classified by Chelsea scale, at the 6th month post-operation revealed to be similar in both groups. Conclusion PRF did not show the effect on bone healing at 6 months after alveolar cleft bone grafting assessed by CBCT and periapical films.