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Title: Skin manifestations in patients with adult-onset immunodeficiency due to anti-interferon-gamma autoantibody : a relationship with systemic infections
Authors: Kamonwan Jutivorakool
Prattana Sittiwattanawong
Kornphaka Kantikosum
Hurst, Cameron P.
Chanat Kumtornrut
Pravit Asawanonda
Jettanong Klaewsongkram
Pawinee Rerknimitr
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Other author: Chulalongkorn University. Faculty of Medicine
Issue Date: Sep-2018
Publisher: Acta Dermato-Venereologica
Citation: Acta Dermato-Venereologica, Vol.98. No. 8 (Sep. 2018) , p. 742-747.
Abstract: Adult-onset immunodeficiency due to anti-interferon-γ autoantibody is an emerging acquired immunodeficiency with frequent skin manifestations. A retrospective chart review was conducted and identified 41 patients with the syndrome. Skin involvement was detected in 33 (80%) patients, 15 (45%) with infective skin diseases and 27 (82%) with reactive skin disorders. Reactive lesions were mostly neutrophilic dermatoses, e.g. Sweet syndrome. Of note, the presence of neutrophilic dermatoses was highly associated with infections of other sites. An adjusted odds ratio for the existence of infections in patients with neutrophilic dermatoses was 14.79 (95% CI: 5.13, 42.70; p < 0.001). Moreover, neutrophilic dermatoses were significantly correlated with opportunistic infections observed in those with defects in cell-mediated immunity including non-tuberculous mycobacterium and disseminated fungal infection. The odds ratio for opportunistic infections in the presence of neutrophilic dermatoses was 12.35 (95% CI: 5.00, 30.55; p < 0.001). Thus, the presence of neutrophilic dermatoses in patients with the syndrome can signal opportunistic infections that warrant physician attention.
ISSN: 0001-5555
metadata.dc.identifier.DOI: 10.2340/00015555-2959
Type: Article
Appears in Collections:Chula Scholars - 2018

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