Please use this identifier to cite or link to this item: http://cuir.car.chula.ac.th/handle/123456789/61681
Title: Domain rearrangement and denaturation in Ebola virus protein VP40
Authors: Pokhrel, Rudramani
Pornthep Sompornpisut
Chapagain, Prem
Olson, Brian
Gerstman, Bernard
Pandey, R. B.
Email: No information provided
Pornthep.S@Chula.ac.th
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Other author: Chulalongkorn University. Faculty of Science
Issue Date: 31-Dec-2018
Publisher: American Institute of Physics
Citation: AIP Advances, Vol.8, No.12 (Dec., 2018) ; 8 pages
Abstract: The VP40 protein plays a critical role in coordinating the virion assembly, budding, and replication of the Ebola virus. Efforts have been made in recent years to understand various aspects of VP40 structure, dynamics, and function such as assembly of the protein and its roles in virus replication and penetration of the protein into the plasma membrane. A major conformational transformation is necessary for VP40 to form some of its oligomeric structures and to perform various functions. This conformational change from a compact structure with the N-terminal domain (NTD) and C-terminal domain (CTD) closely associated involves a dissociation or springing-out of the CTD from the NTD. We perform investigations using computational molecular dynamics simulations as well as knowledge-based Monte Carlo simulations. We find that a sharp springing of the CTD from the NTD in a free VP40 protein cannot occur solely by random thermal fluctuations without intermediate oligomerized segments, and therefore is likely triggered by additional molecular events.
URI: http://cuir.car.chula.ac.th/handle/123456789/61681
URI: https://doi.org/10.1063/1.5063474
https://aip.scitation.org/doi/10.1063/1.5063474
ISSN: 2158-3226
metadata.dc.identifier.DOI: 10.1063/1.5063474
Type: Article
Appears in Collections:Chula Scholars - 2018

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