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Title: Characteristics of Curcumin-Loaded Bacterial Cellulose Films and Anticancer Properties against Malignant Melanoma Skin Cancer Cells
Authors: Chayut Subtaweesin
Wannipa Woraharn
Siriporn Taokaew
Nadda Chiaoprakobkij
Amornpun Sereemaspun
Muenduen Phisalaphong
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Other author: Chulalongkorn University. Faculty of Medicine
Chulalongkorn University. Faculty of Science
Issue Date: 20-Jul-2018
Publisher: MDPI AG
Citation: Applied Sciences. Vol.8, Issue 7 (Mar 2018), 15 pages
Abstract: Curcumin-loaded bacterial cellulose films were developed in this study. Curcumin was absorbed into never-dried bacterial cellulose pellicles by 24-h immersion in solutions of curcumin in the range of 0.2–1.0 mg /mL. The curcumin-loaded bacterial cellulose pellicles were then air-dried and characterized. The mechanical properties of curcumin-loaded bacterial cellulose films, particularly the stretching properties, appeared to be lower than those of bacterial cellulose film. This was especially evident when the loading concentration of curcumin was higher than 0.4 mg/mL. Fourier-transform infrared spectroscopy analysis indicated an interaction between bacterial cellulose microfibrils and curcumin. Controlled release of curcumin was achieved in buffer solutions containing Tween 80 and methanol additives, at pH 5.5 and 7.4. Curcumin-loaded bacterial cellulose films prepared with curcumin solutions at concentrations of 0.5 and 1.0 mg/mL displayed antifungal activities against Aspergillus niger. They also exhibited anticancer activity against A375 malignant melanoma cells. No significant cytotoxic effect was observed against normal dermal cells, specifically, human keratinocytes and human dermal fibroblasts
ISSN: 2076-3417
metadata.dc.identifier.DOI: 10.3390/app8071188
Type: Article
Appears in Collections:Chula Scholars - 2018

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