Please use this identifier to cite or link to this item: http://cuir.car.chula.ac.th/handle/123456789/61728
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dc.contributor.authorZhang, Huoru-
dc.contributor.authorZhang, Yan-
dc.contributor.authorWang, Yong-Fei-
dc.contributor.authorMorris, David-
dc.contributor.authorNattiya Hirankarn-
dc.contributor.authorSheng, Yujun-
dc.contributor.authorShen, Jiangshan-
dc.contributor.authorPan, Hai-Feng-
dc.contributor.authorYang, Jing-
dc.contributor.authorYang, Sen-
dc.contributor.authorCui, Yong-
dc.contributor.authorYe, Dong-Qing-
dc.contributor.authorVyse, Timothy J.-
dc.contributor.authorZhang, Xuejun-
dc.contributor.authorLau, Yu Lung-
dc.contributor.authorYang, Wanling-
dc.contributor.otherChulalongkorn University. Faculty of Medicine-
dc.date.accessioned2019-05-12T09:52:15Z-
dc.date.available2019-05-12T09:52:15Z-
dc.date.issued2018-05-03-
dc.identifier.citationArthritis Research & Therapy. Vol.20, Article no. 92 (2018), 8 pagesen_US
dc.identifier.issn1478-6362-
dc.identifier.urihttp://cuir.car.chula.ac.th/handle/123456789/61728-
dc.description.abstractBackground : Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of populations of both Chinese and European origin. Methods : This study involved 5695 cases and 10,357 controls in the discovery stage. The lead signal on chromosome X was followed by replication in three additional Asian cohorts, with 2300 cases and 4244 controls in total. Conditional analysis of the known associated loci on chromosome X was also performed to further explore independent signals. Results : Single-nucleotide polymorphism rs13440883 in GPR173 was found to be significantly associated with SLE (Pmeta = 7.53 × 10− 9, ORmeta= 1.16), whereas conditional analysis provided evidence of a potential independent signal in the L1CAM-IRAK1-MECP2 region in Asian populations (rs5987175 [LCA10]). Conclusions : We identified a novel SLE susceptibility locus on the X chromosome. This finding emphasizes the importance of the X chromosome in disease pathogenesis and highlights the role of sex chromosomes in the female bias of SLE.en_US
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.urihttps://doi.org/10.1186/s13075-018-1590-3-
dc.relation.urihttps://arthritis-research.biomedcentral.com/articles/10.1186/s13075-018-1590-3-
dc.rights© The Author(s) 2018en_US
dc.titleMeta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLEen_US
dc.typeArticleen_US
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNattiya.H@Chula.ac.th-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.email.authorNo information provided-
dc.subject.keywordSystemic lupus erythematosusen_US
dc.subject.keywordX chromosomeen_US
dc.subject.keywordAssociationen_US
dc.subject.keywordGeneticsen_US
dc.subject.keywordSingle-nucleotide polymorphismsen_US
dc.identifier.DOI10.1186/s13075-018-1590-3-
Appears in Collections:Chula Scholars - 2018

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