Please use this identifier to cite or link to this item: http://cuir.car.chula.ac.th/handle/123456789/61728
Title: Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE
Authors: Zhang, Huoru
Zhang, Yan
Wang, Yong-Fei
Morris, David
Nattiya Hirankarn
Sheng, Yujun
Shen, Jiangshan
Pan, Hai-Feng
Yang, Jing
Yang, Sen
Cui, Yong
Ye, Dong-Qing
Vyse, Timothy J.
Zhang, Xuejun
Lau, Yu Lung
Yang, Wanling
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Nattiya.H@Chula.ac.th
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Other author: Chulalongkorn University. Faculty of Medicine
Issue Date: 3-May-2018
Publisher: BioMed Central Ltd.
Citation: Arthritis Research & Therapy. Vol.20, Article no. 92 (2018), 8 pages
Abstract: Background : Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of populations of both Chinese and European origin. Methods : This study involved 5695 cases and 10,357 controls in the discovery stage. The lead signal on chromosome X was followed by replication in three additional Asian cohorts, with 2300 cases and 4244 controls in total. Conditional analysis of the known associated loci on chromosome X was also performed to further explore independent signals. Results : Single-nucleotide polymorphism rs13440883 in GPR173 was found to be significantly associated with SLE (Pmeta = 7.53 × 10− 9, ORmeta= 1.16), whereas conditional analysis provided evidence of a potential independent signal in the L1CAM-IRAK1-MECP2 region in Asian populations (rs5987175 [LCA10]). Conclusions : We identified a novel SLE susceptibility locus on the X chromosome. This finding emphasizes the importance of the X chromosome in disease pathogenesis and highlights the role of sex chromosomes in the female bias of SLE.
URI: http://cuir.car.chula.ac.th/handle/123456789/61728
URI: https://doi.org/10.1186/s13075-018-1590-3
https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-018-1590-3
ISSN: 1478-6362
metadata.dc.identifier.DOI: 10.1186/s13075-018-1590-3
Type: Article
Appears in Collections:Chula Scholars - 2018

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