Please use this identifier to cite or link to this item: http://cuir.car.chula.ac.th/handle/123456789/61832
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNootchanat Mairuae-
dc.contributor.authorPoonlarp Cheepsunthorn-
dc.contributor.otherChulalongkorn University. Faculty of Medicine-
dc.date.accessioned2019-05-15T11:17:06Z-
dc.date.available2019-05-15T11:17:06Z-
dc.date.issued2018-04-
dc.identifier.citationBiomedical Reports. Vol.8, Issue 4 (Apr, 2018), p.359-364en_US
dc.identifier.issn2049-9434 (Print)-
dc.identifier.issn2049-9442 (Online)-
dc.identifier.urihttp://cuir.car.chula.ac.th/handle/123456789/61832-
dc.description.abstractIron accumulation in activated microglia has been consistently reported in neurodegenerative diseases. Previous results suggest that these cells facilitate neuroinflammation leading to neuronal cell death. Therefore, chemical compounds that alleviate the activation of iron‑rich microglia may result in neuroprotection. In the present study, the effect of valproic acid (VPA) on microglial activation under iron‑rich conditions was investigated. BV‑2 microglial cells were exposed to lipopolysaccharide (LPS; 1 µg/ml) and iron (300 µg/ml) with or without VPA (1.6 mM). The results demonstrated that VPA attenuated the activation of iron‑rich BV2 cells induced by LPS by down‑regulating the mRNA expression of inducible nitric oxide (NO) synthase and interleukin 1β (IL‑1β; P<0.01), to ultimately reduce the production of NO and IL‑1β (P<0.01). These events were accompanied by an attenuation in the nuclear translocation of nuclear factor‑κB p65 subunit (P<0.01). These findings suggest that VPA may be therapeutically useful for attenuating the activation of iron‑rich microglia.en_US
dc.language.isoenen_US
dc.publisherSpandidos Publicationsen_US
dc.relation.urihttps://doi.org/10.3892/br.2018.1062-
dc.relation.urihttps://www.spandidos-publications.com/10.3892/br.2018.1062-
dc.rights© Spandidos Publications UK Ltden_US
dc.titleValproic acid attenuates nitric oxide and interleukin‑1β production in lipopolysaccharide‑stimulated iron‑rich microgliaen_US
dc.typeArticleen_US
dc.email.authorNo information provided-
dc.email.authorPoonlarp.C@Chula.ac.th-
dc.subject.keywordironen_US
dc.subject.keywordinterlukin‑1βen_US
dc.subject.keywordmicrogliaen_US
dc.subject.keywordnitric oxideen_US
dc.subject.keywordvalproic aciden_US
dc.identifier.DOI10.3892/br.2018.1062-
Appears in Collections:Chula Scholars - 2018

Files in This Item:
File Description SizeFormat 
html_submission_64755.htmlLink to Fulltext2.8 kBHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.