Cytotoxicity of Kaempferia parviflora against breast cancer cell lines

Abstract

Nine flavonoids, one curcumin and one sugar, namely, 3, 5, 7 - trimethoxyflavone (1), 5, 7 - dimethoxyflavone (2), 5, 7, 4' - trimethoxyflavone (3), 4' - hydroxy - 5, 7 - dimethoxyflavone (4), dicinnamoylmethane (5), 5 - hydroxy - 3 , 7 - dimethoxyflavone (6), 5 - hydroxy - 7 - methoxyflavone (7), 5 - hydroxy - 3, 7, 4' - trimethoxyflavone (8), 5 - hydroxy - 7, 4' - dimethoxyflavone (9), 5, 7 - dimethoxyflavanone (10) and sucrose (ID were isolated from black rhizome of Kaempferia parviflora. Each compound was tested for cytotoxicity against various human tumor cell lines BT474 (breast), SW620 (colon), KATO - 3 (gastic), CHAGO (lung), HEP - G2 (hepatoma) and HS27 (fibroblast) by MTT method and tested for antioxidant activity by DPPH method. It was found that compound 2 and 10 showed cytotoxicity against Kato3 cell lines, compound 3 showed cytotoxicity against Hep-G2, Kato-3, Chago cell lines, compound 6 showed cytotoxicity against Hep-G2 and Kato-3 cell lines, compound 7 showed cytotoxicity against Chago, Kato-3 and SW620 cell lines, compound 9 showed cytotoxicity against Kato-3 and SW620 cell lines. Compound 5 has weak antioxidant activity.