Immunomodulation of WF10(TCDO) and its effect with porphyromonas gingivalis

Abstract

WF10 is a chlorite-oxygen compound TCDO (tetrachlorodecaoxygen) with unique biochemical and pharmacological properties cliamed by the manufacturer; 0X0 chemie. The key features of WF10 are the ability to activate phagocytic cells, enhance wound healing and inhibit bacterial growth. Thus, the compound may have therapeutic application in periodontitis. Here, we describe the immunomodulatory effects of WF10 alone and in combination with Porphyromonas gingivalis in peripheral blood mononuclear cell cultures. WF10 at the non-toxic concentration upregulated CD69 expression on different mononuclear cell subsets and also induced moderate amount of IL-12 (p40), TNF- α, and IFN-y production. When combined with Porphyromonas gingivalis, WF10 enhanced Porphyromonas gingivalis-induced TNF- α production, but greatly down-regulated Porphyromonas gingivalis-induced IL-1β production. Overall, our study does not provide enough information to draw any conclusions on therapeutic effect of WF10 in peridontitis, but it does provide an interesting data on the immunomodulatory effect of WF10 on Porphyromonas gingivalis-induced immune activation. Further study is required to better understand how WF10 effects Porphyromonas gingivalis-induced pathological process before the compound could find its place in clinical application.