Chondroprotective efficacy of undenatured collagen type II on canine osteoarthritis secondary to medial patellar luxation

Abstract

Osteoarthritis (OA) is found secondary from medial patellar luxation (MPL) which is one of the most common diseases in small-breed dogs. Managements of the disease are surgical correction or a medical treatment. In the patients who are unable to do the surgical correction, non-steroidal anti-inflammatory drugs (NSAIDs) remains the drug of choice for OA therapy. Nowadays nutraceuticals have become more popular since there are no side effects once given for a long period of time. The purpose of this study was to evaluate the clinical chondroprotective effects of undenatured collagen type-II (UCII) on OA secondary to canine medial patellar luxation. Nine small-breed dogs received UCII for 120 days. Ultrasonographic, radiographic examinations, lameness score, blood collection and CBPI were evaluated for comparison the results between before and after received UCII. One-Way Anova and paired T-test was used to analyze the statistical significance of data. The results revealed a statistically significant difference between before and after received UCII in CBPI (p-value <0.05). Lameness score, radiographic examinations and blood collection were no significantly different. CBPI and the ultrasonographic scores has significantly improve even if only joint effusion from all of ultrasonographic examination was significant difference. In conclusion, UCII may be the choice of OA nutraceutical chondroprotective products which could be a co-treatment with the MPL treatment as UCII can improve the clinical signs.