Chemical constituents of the stem bark of croton roxburghii from Nahaew District, Loei province

Abstract

In the investigation of chemical constituents of the stem bark of Croton roxburghii N.P. Balakr., two town labdane diterpenes, (5S, 8S, 9S, 10R, 13S)-8, 13 - epoxylabda - 1, 14-diene-3-one (1) and (5S, 8S, 9S, 10R, 13S)-8, 13-epoxy-12-hydroxylabda-1, 14-diene-3-one (2) were isolated from crude hexane extract. The structures of these compounds were established by analysis of their spectroscopic data (UV, IR, MS 1-D NMR, 2-D NMR, CD and X-ray diffraction analysis). Each compound was tested for cytotoxicity against various human tumor cell lines: BT 474 (breast cancer), HEP-G2 (hepatoma), SW 620 colon cancer), CHAGO (lung cancer), KATO-3 (gastric cancer). Both compounds showed weak cytotoxic activity against all cancer cell lines tested.