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Please use this identifier to cite or link to this item: https://cuir.car.chula.ac.th/handle/123456789/27769
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dc.contributor.advisorสุมนา ชมพูทวีป
dc.contributor.advisorสมัย ลีพัฒน์ไพบูลย์
dc.contributor.authorอรวรรณ กิจควร
dc.contributor.otherจุฬาลงกรณ์มหาวิทยาลัย. บัณฑิตวิทยาลัย
dc.date.accessioned2012-12-15T18:04:05Z
dc.date.available2012-12-15T18:04:05Z
dc.date.issued2543
dc.identifier.isbn9743348913
dc.identifier.urihttp://cuir.car.chula.ac.th/handle/123456789/27769
dc.descriptionวิทยานิพนธ์ (วท.ม.)--จุฬาลงกรณ์มหาวิทยาลัย, 2543en
dc.description.abstractalternativeThe purpose of this study was to determine the bioequivalence of two postcoital contraceptives containing levonorgestrel 0.75 mg which were local and original product. The experiment was assigned to be randomized crossover design in 12 healthy Thai female volunteers who were given a single oral dose of levonorgestrel 0.75 mg (1 tablet) and blood samples were drawn at O, 1, 1.5, 2, 2.5 3, 3.5, 4, 6, 10 and 24 hrs after drug administration. The plasma drug concentration was determine by radioimmunoassay and analyzed for pharmacokinetic parameters of levonorgestrel. The results present that the peak plasma concentration (C[subscript max]), the time to peak plasma concentration (t[subscript max]) and area under the plasma concentration time curve (AUC) between two product were statistically difference (p<0.05). Difference of t[subscript max] equals 55.08% and the 90% Confidence interval for the difference of C[subscript max] and AUC means based on log transformed data of two products were within 9.24-124.29% and 65.13-105.67% respectively, referring, the two postcoital contraceptives were not bioequivalence.
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dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
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dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isothes
dc.publisherจุฬาลงกรณ์มหาวิทยาลัยen
dc.rightsจุฬาลงกรณ์มหาวิทยาลัยen
dc.titleการศึกษาชีวสมมูลของยาคุมกำเนิดหลังร่วมเพศ (ลีโวนอร์เจสเตรล 0.75 มิลลิกรัม) สองชนิดในสตรีไทยen
dc.title.alternativeThe bioequivalence study of two postcoital contraceptives (levonorgestrel 0.75 mg.) in Thai womenen
dc.typeThesises
dc.degree.nameวิทยาศาสตรมหาบัณฑิตes
dc.degree.levelปริญญาโทes
dc.degree.disciplineเภสัชวิทยา (สหสาขาวิชา)es
dc.degree.grantorจุฬาลงกรณ์มหาวิทยาลัยen
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