Statistical analysis for parentage test and mutation rate determination in Thai database

Abstract

Using DNA fingerprinting to determine the relationship parents and children from families that are not relatives, each of 1,011 families. By the Profiler Plus on 9 STR loci to establish in relationship parents and children of 324 families. For the Identifiler on 15 STR loci used to detect relationships between fathers-children and mothers-children of 305 families and 382 families respectively. To calculate the combined paternity index (CPI) or the combined maternity index (CMI) and to collect the event of a mutation in some families. The results showed that in the examination of parent and child relationship with the CPI of 376 values which were the CPI values between 420.07 to 359,558,681.35. Examination of the relationship between the father – child with the CPI of 423 values were between 228.71 to 38,900,000,000 and monitoring the relationship between the mother - child of 543 values were between 70.45 to 1,730,000,000. In the case of the mutation was found for 35 cases with a characteristic mutation in two forms. Is to turn the feature on the increase or decrease of the base sequence repeat of 34 cases and feature a single base change in one case. This report presents data that will be used to determine the appropriateness of the CPI or the CMI to a minimum at the conclusion of a father and / or mother of child's true blood.