Synthesis of isothiazolopyrimidine derivatives as potential antimicrobial agents

Abstract

This study was to synthesized the new organic compounds which expected to have antimicrobial activity and to study the synthetic process of isothiazolopyrimidine derivatives. The synthesis of isothiazolopyrimidine derivatives starting from the reaction of 3,5-diaminoisothiazole derivatives and isothiocynates to yield the N-isothiazolyl thioureas which were then cyclized by heating yielded eight desired products, four 5-substituted-3-substituted aminoisothiazolo[3,4-dyrimidine-4-one-6(7H)-thiones and four 5,7-disubstituted-3-aminoisothiazolo[5,4-d]pyrimidine-4-imone-6-thiones; and also eight intermediates, two 3-amino-4-carbethoxy-5-substituted aminoisothiazolo, two 3-amino-4-cyano-5-substituted aminoisothiazoles and four N-substituted-N’-(4-carbethoxy-5-substituted aminoisotiazolyl)-thioureas.