Chemical constituents of the marine sponge, Ircinia sp.

Abstract

The brine shrimp lethality assay-directed fractionation of the dichloromethane extract from a marinc sponge Ircinia sp. led to the isolation of 3 linear furanoterpenes including, anhydrofurospongin-1, furodendin, and furospongolide, together with one methyl scalarane, 22-acetoxyl-16beta-hydroxy-24-methyl-24-oxoscalaran-25, 12beta-olactone. Structure elucidations of the isolated compounds were executed by extensive analysis of their ir, uv, ms, 1-D nmr and 2-D nmr spectral data, as well as comparison with the literatures. Anhydrofurospongin-1 showed activity in brine shrimp lethality assay at LD50 2.38 mug/ml and also showed moderate anti HSV-1 activity at concentration 20 mug/ml, while furospongolide showed only moderate anti HSV-1 activity at the same concentration.