Chemical constituents of the heartwood of xylia xylocarpa var. kerrii

Abstract

Two new pimarane-type siterpenoids are 8(9), 15-isopimaradiene-3one,14B-ol and sandaracopimaradiene-2a,3B-diol in the course of the investigation for chemical constituents of dried heartwood of Wylia xylocarpa var. kerrii from Loei and mae Hong Son province. Moreover, the were a mixture of B-sitosterol and stigmasterol and 4 pimarane-type diterpenoid compounds such as sandaracopimaradiene-3B, 18-diol, sandaracopimaradiene-3-one, sandaracopimaradiene-3B-ol, sandaracopimric acid. the structure of these compounds were established by analysis of their spectroscopic data (UV, IR, MS, 1D-NMR, 2D-NMR analysis) as well as comparison with previously reported values. each compound was tested in vitro cytotoxicity against 5 human cancer cell lines; KATO-3 (human gastric carcinoma), SW620 (human colon adenocarcinoma), BT474(human breast ductal carcinoma), HEP-G2(human liver hepatoblastoma), CHGO(human undifferentiated lung carcinoma). the pimarane-type diterpeniods such as sandaracopimaradiene-3B, 18-diol, sandaracopimaradiene-3-one, sandaracopimaradiene-3B-ol, sandaracopimaric acid and 8(9), 15-isopimaradiene-3-one, 14B-ol showed strong and moderate cytotoxic activity against 5 human cancer cell lines but sandaracopimaradiene-2a,3B-diol was inactived all tested cancer cell lines.