Pretreatment prognostic factors to predict survival outcome in advanced non-small cell lung cancer with first line treatment in Thailand: a retrospective cohort study

Abstract

Background: Tumor genetic information and biologic markers are often used as prognostic factors. However, these have limited applicable in real daily practice due to their high cost . Objective: To evaluate which inexpensive, convenient simple prognostic factors are associated with survival outcome with first line treatment among patients with advanced non-small cell lung cancer (NSCLC). Methods: Retrospectively reviewed the charts of patients diagnosed with having advanced NSCLC with no previous treatment seen at King Chulalongkorn Memorial Hospital and Police General Hospital during 1 January 2008-31 Dec 2013. Results: A total of 301 patients were included in the study; 68.1% males. The pretreatment prognostic factors found to be significantly associated with outcome were: the number of organs involved (p<0.05),simple biomarkers: the absolute neutrophil lymphocyte count ratio (p<0.001) albumin globulin ratio (p=0.010)and the ,ECOG status ( p<0.005),and current smoker(p=0.001) Conclusion: The pretreatment prognostic factors significantly associated with outcome were the number of organs involved, the neutrophil absolute lymphocyte ratio and , ECOG status and smoking status. These factors could potentially be used to develop a simple model to determine pretreatment prognosis among NSCLC patients.