Development and characterization of bisdemethoxycurcumin-loaded solid lipid nanoparticles

Abstract

The aim of study was to develop solid lipid nanoparticles containing bisdemethoxycurcumin using rice bran wax compared to glyceryl behenate and cetyl palmitate for pharmaceutical application. Rice bran wax is a by-product from rice bran oil refinery. It contains potent antioxidant of gamma oryzanol utilized in pharmaceuticals. Solid lipid nanoparticles (SLN) were prepared by high pressure homogenization technique using different type and amount concentration of lipid, and stabilized by tween 80. Type and concentration of lipids influenced the physicochemical properties of the SLN. RB-SLN had larger particle size than GB-SLN and CP-SLN. The higher the concentration of lipid, the larger was the particle size. Also, the higher the amount of tween 80 in SLN, the better was physical stability. Bisdemethoxycurcumin-loaded SLN (BDMC-SLN) appeared as a homogeneous dispersion with spherical shape in nanosize range. BDMC-SLN with RB had the largest particle size and the highest entrapment efficiency. In vitro release study of the BDMC-SLN exhibited a sustained release pattern. Increasing the lipid concentration resulted in sustaining the BDMC released. BDMC-loaded solid lipid nanoparticles using rice bran wax was successfully prepared. This rice bran lipid carrier provided better physical properties, entrapment efficiency and stability.