Chitosan derivative nanoparticles for controlled release of aldehydes

Abstract

This research was able to prepare double barrier controlled release system consisting of a polymeric barrier through chitosan’s derivation (N-succinylchitosan) and a chemical barrier through aldehyde’s derivation (Schiff base) under heterogeneous phase reaction. N-succinylchitosan was synthesized based on the reaction of chitosan with succinic anhydride, and the obtained polymer could self-assemble into spherical nanoparticles in aqueous medium. The amino groups on the surface of the obtained particles could form Schiff base with fragrant aldehydes including vanillin, cinnamaldehyde, citronellal and citral. All the Schiff base moieties were located at the inside of the particles as confirmed by X-ray photoelectron spectroscopic analysis (XPS). All obtained Schiff base nanoparticles gave stable nanospheres, whose hydrodynamic diameters were in the range of 80 to 165 nm. The prolonged release of the grafted aldehydes from the obtained double barrier systems was demonstrated.