Factors related to decision-making towards participation in clinical trials in diabetes patients at King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Abstract

Presently, the proportion of clinical trials conducted in Thailand is continuously increased and growth. This reflects number of patients in clinical trial is also increased which brings Thai patients are more involved in clinical trial participation in this decade. Beyond the risks and benefits from clinical trial participation, there are other influential factors that influence patients to decide to participate or decline to participate in the clinical trials. A descriptive, cross-sectional research design through self-questionnaire data collection method described factors related to the decision making process regarding participation in clinical trials. The study was conducted in diabetes patients at King Chulalongkorn Memorial Hospital, Bangkok, Thailand. The sample consisted of 110 diabetes patients. Multiple logistic regression analysis was used to examine factors that influence phase III clinical trial participation. Logistic regression analyses showed that the factors best explaining participation were knowledge about clinical trial (p=0.007), attitude towards clinical trial participation (p<0.001), and patient with single status (p=0.025). This research is expected to collect some information about the factors related to decision-making towards participation in clinical trials in diabetes patients at the King Chulalongkorn Memorial Hospital. The results of this research can make a difference in the study towards patients’ knowledge and attitude towards clinical trial participation.