Effect of CU 763-14-07 and CU 763-14-10 on behavioural despair and motor activity in animal models and on brain monoamine neurotransmitter levels

Abstract

The investigation was to study antidepressant activity of synthesized chemicals, CU 763-14-07 and CU 763-14-10 which were performed in Swiss Albino mice by using animal models as the following 1. Behavioral despaired test (Forced swimming test) 2. Activity test and 3. Rota rod test. In addition, the measurement of the levels of central monoamine neurotransmitters: Noradrenaline (NE), Dopamine (DA), and Serotonin (5-HT) was performed in the whole rat brain. The results revealed that CU 763-14-07 (10 mg/kg and 20 mg/kg i.p.) and CU 763-14-10 (20 mg/kg i.p.) significantly decreased the immobility time on behavioral despaired test. In locomotor activity test, neither CU 763-14-07 nor CU 763-14-10 with the dose that decrease immobility time caused alteration in motor activity. These results suggest that the antidepressant-like effect of those agents are not due to increase in locomotor activity. For Rota rod test, none of those agents affected motor deliberation. In determination of level of neurotransmitters show that CU 763-14-07 significantly and selectively increased NE while CU 763-14-10 significantly increase the amounts of NE, DA, and 5-HT. These may potentiate in prediction the antidepressant activity of the above agents. The results from this studies demonstrated that both of them have antidepressant activity, thus further studies will be required to verify the mechanism of action, the pharmacological profile, efficacy, and safety of compounds.