Tablet disintigrating property of sodium carboxymethylcellulose cross-linked with sodium trimetaphosphate

Abstract

The disintegrating property of sodium carboxymethylcellulose cross-linked with sodium trimetaphosphate was evaluated and compared to that of sodium carboxymethylcellulose used as starting material, Ac-di-sol® , Nymcel® , Primojel®, and corn starch. Certain physical parameters of the disintegrants (water uptake, swelling, sedimentation volume and hydration capacity) were determined for the purpose of differentiation their relative efficiency. It was postulated that swelling of cross-linked sodium carboxymethylcellulose appeared to be responsible for its tablet disintegration property. Cross-linked sodium carboxymethylcellulose demonstrated superior disintegrating property over unmodified sodium carboxymethylcellulose and comparable to Ac-di-sol® , Nymcel® , Primojel® corn starch in the soluble tablet formulations made by direct compression. Whereas in insoluble tablet formulations cross-linked sodium carboxymethylcellulose showed more effective than unmodified sodium carboxymethylcellulose and corn starch and inferior to Ac-di-sol® , Nymcel® , Primojel®. In paracetamol tablets with 4% disintegrant, the disintegration testing results indicated that cross-linked sodium carboxymethylcellulose was superior to unmodified sodium carboxymethylcellulose but not as effective as Ac-di-sol® , Nymcel® , Primojel® and corn starch. And T80% of paracetamol tablet containing modified sodium carboxymethylcellulose, Ac-di-sol® , Nymcel® , Primojel® was shorter than corn starch. Formulation containing unmodified sodium carboxymethylcellulose did not meet official compendial (USP XXIII) requirement of 80% (Q) drug dissolved in 30 minutes.