Development of terbutanine sulfate transdermal patch by using chitosan and polyvinyl derivatives as adhesive ma

Abstract

Terbutaline sulfate transdermal patch was developed by using chitosan and polyvinyl derivatives as adhesive matrices. Selected polyvinyt derivatives used in this experiment were polyvinyl alcohol and polyvinylpyrrolidone K-90 In preliminary study, transdemal patches with adhesive property were prepared by using chitosan and polyvinylpyrrolidone K-90 blend. Glycerin was used as a plasticizer. The formulations, which produced good physical characteristics and adhesiveness, was selected for preparing terbutaline sulfate transdermal patch. The physicochemical properties of terbutaline sulfate transdermal patches, which composed of physical, moisture sbsorption, mechanical, adhesive and thermal pxoperties, were cvaluated. In-vitro skin permeation studywas also evaluated by using shed snake skin. The difference in physicochemical properties was affected by the molecular weight and amount of chitosan and amount of polyvinylpyrrolidone K-90 , thus in turn affected the drug permeation through shed snake skin. The skin permeation of terbutatine sulfate was controlled by diffusion through structure of adhesive matrix. It can be summarized that matrix controlled terbutaline sulfate transdermal patch using chitosan blended with polyvinylpyrrolidone K-90 and glycerin in a concentration of 10% w/w to increase adhesiveness could exhibit could exhibit 1.202 ug/hr/cm2of drug permeation.