Process optimization designs base on silk fibroin protein in unique polymeric morphology for wound dressing application

Abstract

Nowadays, there are numerous researches regarding to the relative efficiency of the various kinds of material for effective wound healing. Biopolymers and fabrication techniques have been studied not only for covering in order to prevent infection but also have extraordinary properties which promote the healing process. In this work, Thailand domesticated, Bombyx mori, silk fibroin fibres, which is well known in the textile industry for centuries, was used to develop as active wound dressing. Silk fibroin from the silk cocoon is generally defined as an attractive biomaterial because of its unique characteristics such as high mechanical strength, excellent biocompatibility, controllable structure and morphology, and wide variety of constructive properties on tissue engineering. One of the most effective methods for this is electrospinning, a proven technique that precisely creates the fibrous structure that can mimic nanofibrillar structure and the biological functions of the natural extracellular matrix. Electrospun fibrous mats also combine extremely large surface area to volume ratios with high porosity, features that are needed for the application of these materials in wound healing. In this study, we aimed to optimize the preparation process of ultra-fine silk fibroin fibers for wound dressing application. These findings open an exciting opportunity to fabricate biocompatible scaffold structures that could be used as next generation effective wound healing materials.