Chondroprotective efficacy of pcso-524 on canine osteoarthritis secondary to medial patellar luxation

Abstract

Fifty stifles from Pomeranians and Chihuahuas with over five years old were enrolled in this study, which are 8 normal stifles and 42 medial patellar luxation (MPL) stifles. All MPL stifles were assigned randomly into 2 groups, including control and treatment groups. The control group was received placebo daily for 16 weeks, while treatment group was fed with PCSO-524 for 16 weeks. Lameness score, ultrasonographic findings, radiographic OA score and owner questionnaire (cBPI) were assessed at pre-treatment (D0) and post-treatment at week 2, 4, 8, 12 and 16. The ultrasonographic evaluations consisted of synovial fluid, articular cartilage, bone surface and ultrasonographic score. In treatment group, the ultrasonographic, synovial fluid and articular cartilage score of proximo-medial femoral condyle were found a significant improvement after 4 week of treatment. The radiographic OA score was significant improvement after 12 weeks of treatment while lameness score and cBPI were found a better outcome within 2 weeks. This study revealed that PCSO-524 has an effectiveness of cartilage protection in dogs with OA secondary to MPL. The surgical procedures are remain suggested in order to decreasing progressive OA. However, MPL dogs are recommended for training quadriceps muscle and environmental managements with administration of PCSO-524 for better quality of life.