CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF AFGEKIA MAHIDOLIAE LEAVES

Abstract

Antioxidant activities of the extracts of A. mahidoliae Burtt et Chermsir (Fabaceae) leaves were evaluated using DPPH radical scavenging and ferric reducing antioxidant power (FRAP) assays. Chemical constituents of the ethyl acetate and n-butanol extracts, which displayed strong activities, were further studied. Five flavonoid glycosides, juglanin, astragalin, nicotiflorin, isoquercetin and apigenin-7-O-glucuronide, were isolated from the ethyl acetate extract, while a hydroquinone glycoside, arbutin was obtained from the n-butanol extract. The chemical structures of these plant constituents were determined by spectroscopic techniques (UV, IR, MS, and NMR), and comparison with previously reported data. Juglanin and nicotiflorin were able to promote the fibroblasts migration in the in vitro scratch-wound healing assay.