Please use this identifier to cite or link to this item: https://cuir.car.chula.ac.th/handle/123456789/62320
Title: Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade
Authors: Pirom Noisumdaeng
Kantima Sangsiriwut
Jarunee Prasertsopon
Chompunuch Klinmalai
Sunchai Payungporn
Anek Mungaomklang
Kulkanya Chokephaibulkit
Rome Buathong,
Arunee Thitithanyanont
Pilaipan Puthavathana
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Sunchai.P@Chula.ac.th
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Other author: Chulalongkorn University. Faculty of Medicine
Issue Date: 14-Dec-2018
Publisher: Nature Publishing Group
Citation: Emerging Microbes & Infections. vol.7 Issue 1 (2018), 12 pages
Abstract: Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). The EV71 subgenotype C4b was introduced into Thailand for the first time in 2006 and was replaced by subgenotype C4a strains in 2009. Phylogenetic, similarity plot and bootscan analyses of the complete viral genomes identified 12 recombinant viruses among the 32 viral isolates. Only one EV71-B5 isolate out of 20 was a recombinant virus with one region of intratypic or intertypic recombination, while all four EV71-C4 isolates were recombinant viruses having undergone double recombination, and all seven CA16 isolates were recombinant viruses. The recombination breakpoints of these recombinants are located solely within the P2 and P3 regions. Surveillance for circulating strains and subgenotype replacement are important with respect to molecular epidemiology and the selection of the upcoming EV71 vaccine. In addition, the clinical importance of recombinant viruses needs to be further explored.
URI: http://cuir.car.chula.ac.th/handle/123456789/62320
URI: https://doi.org/10.1038/s41426-018-0215-x
https://www.tandfonline.com/doi/full/10.1038/s41426-018-0215-x
ISSN: 2222-1751
metadata.dc.identifier.DOI: 10.1038/s41426-018-0215-x
Type: Article
Appears in Collections:Foreign Journal Article

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