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https://cuir.car.chula.ac.th/handle/123456789/80631
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Warinthorn Chavasiri | - |
| dc.contributor.author | Thamolwan Arnanthigo | - |
| dc.contributor.author | Napassakorn Chuaycharoen | - |
| dc.contributor.other | Chulalongkorn University. Faculty of Science | - |
| dc.date.accessioned | 2022-10-10T06:47:50Z | - |
| dc.date.available | 2022-10-10T06:47:50Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.uri | http://cuir.car.chula.ac.th/handle/123456789/80631 | - |
| dc.description | In Partial Fulfillment for the Degree of Bachelor of Science Department of Chemistry, Faculty of Science Chulalongkorn University Academic Year 2020 | en_US |
| dc.description.abstract | Synthesized depsides were modified based on the core structure of jaboticabin, to enhance its biological activities. Desired depsides were synthesized through an esterification with methyl 2-(2- hydroxyphenyl) acetate (NT0) and a carboxylic acid compound. DCC and DMAP were required to activate the carboxylic group and solvent used was DCM. 2-(2-Methoxy-2-oxoethyl)phenyl 3- nitrobenzoate (NT1) and 2-(2-methoxy-2-oxoethyl)phenyl (E)-3-(2,6-dichlorophenyl)acrylate (NT18) showed powerful anti ɑ-glucosidase activity with an IC50 value of 68.7 μM and 84.8 μM. The IC50 values obtained from assay were lower than that of Acarbose, the standard reference (IC50 = 93.6 μM). On the other hand, none of the compounds showed good potential towards antioxidant activities. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Chulalongkorn University | en_US |
| dc.rights | Chulalongkorn University | en_US |
| dc.subject | Depsides -- Synthesis | en_US |
| dc.subject | Antioxidants -- Synthesis -- Inhibitors | en_US |
| dc.title | Synthesis of depsides and their biological activity | en_US |
| dc.type | Senior Project | en_US |
| dc.degree.grantor | Chulalongkorn University | en_US |
| Appears in Collections: | Sci - Senior Projects | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 63-SP-BSAC-000 - Thamolwan Arnanthigo.pdf | 62.41 MB | Adobe PDF | View/Open |
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