Please use this identifier to cite or link to this item: https://cuir.car.chula.ac.th/handle/123456789/83857
Full metadata record
DC FieldValueLanguage
dc.contributor.authorเถลิงศักดิ์ กาญจนบุษย์-
dc.contributor.authorกุลวรา เมฆสวรรค์-
dc.contributor.authorอังคณา ตันติธุวานนท์-
dc.contributor.authorวิภาวี กิตติโกวิท-
dc.contributor.authorพรทิพย์สวรรค์ นวลทอง-
dc.contributor.authorพรเพ็ญ พนมวัลย์-
dc.contributor.otherจุฬาลงกรณ์มหาวิทยาลัย. คณะแพทยศาสตร์-
dc.date.accessioned2023-12-08T08:30:30Z-
dc.date.available2023-12-08T08:30:30Z-
dc.date.issued2553-
dc.identifier.urihttps://cuir.car.chula.ac.th/handle/123456789/83857-
dc.description.abstractBackground. The optimal formula of calvitrin based peritoneal dialysis was composing of calvitrin 6.25 g LL~:: electrolytes such as sodium chloride 540 g, sodium lactate 448 mg, calcium chloride 25.7mg and magnesium chloride 5.08 mg Methods. In vitro studies; the cytotoxicity was investigated. Human peritoneal mesothelial cells (HPMC) were isolated and characterized as described in tetail elsewhere (29). Cells were depleated serum and treated with 15% Cal-PD, 7.5% lcodextrin, 1.5% Dextose and media controls for 36 hrs. Cells morphology changes were examined under microscopy. The results found that few changing of cells treating with 15% calvitrin PD (<10%), 7.5% lcodextrin (>20%), 1.5% Dextose (>40%), positive control (>70%) and no changed in negative medium control. Cell injury examination by LOH testing, the cells treated with 10% Calvitrin released LOH not different from that in lcodextrin. Cell death evaluation by Pl staining, there was fewer cell death when compared to glucose. Results. In vivo studies; acute 14-day toxicity test was studied in mice by intravenously injected with 15% calvitrin (dose 5 ml/Kg) and in Sprague Dawley rats by intraperitoneally injected with 15% calvitrin (dose 10 ml/Kg) compared with control group injected with NSS. Clinical signs, body weight, mortality and necropsy finding were evaluated. There were no abnormality symptoms; no mortality and not significant body weight different were noted. No abnormalities were detected at necropsy, and pathology grading was not significantly found. Conclusion. In conclusion, there were no deaths during 2 weeks duration of acute toxicity testing from both intravenous dose 5 ml. Kg- 1 and intraperitoneal dose 10 ml. Kg- 1 of 15%Calvitrin with electrolytes solution compared with normal saline solution. No significant differences of body and organs weight between among control and test group. No significant abnormality finding from pathology and necropsy examination.en_US
dc.description.sponsorshipงานวิจัยนี้ได้รับทุนอุดหนุนการวิจัยจากทุนเสริมรากฐานการวิจัย กองทุนรัชดาภิเษกสมโภช จุฬาลงกรณ์มหาวิทยาลัย ประจำปี 2551en_US
dc.language.isothen_US
dc.publisherคณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยen_US
dc.rightsคณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยen_US
dc.subjectการล้างไตทางช่องท้องen_US
dc.titleการพัฒนาและการศึกษาความเป็นไปได้ในการนำน้ำตาลเชิงซ้อน-แคลวิตินมาผลิตเป็นน้ำยาฟอกไตทางช่องท้องทดแทนน้ำยาฟอกไตมาตรฐานen_US
dc.title.alternativeInnovation and development of Glucose Polymer "Calvitrin" based solution as a standard peritoneal dialysis solutionen_US
dc.typeTechnical Reporten_US
Appears in Collections:Med - Research Reports

Files in This Item:
File Description SizeFormat 
Talerngsak Kan_Res_2553.pdfรายงานการวิจัยฉบับเต็ม (Fulltext)28.87 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.