Abstract:
To summarize evidences of the renoprotective effects of EPO and review the possible mechanisms of
renoprotection provided by EPO. Results: Experimental studies have demonstrated the renoprotective effects of EPO in acute as well as chronic
renal injury models. These renoprotective actions are likely to be mediated by several mechanisms, either directly
or indirectly. However, EPO therapy is also associated with adverse effects.
Conclusion: EPO is potentially a novel renoprotective drug. Clinical use of EPO for renoprotection could not be
beneficial if adverse side effects of EPO have been overcome.
