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Browsing Med - Theses by Author "Apiwat Mutirangura"

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The association between haplotype of PIGR and genetic susceptibility of nasopharyngeal carcinogenesis

Rungnapa Hirunsatit (Chulalongkorn University, 2001)

Nasopharyngeal carcinoma (NPC) is a rare tumor in the Western world but occurs at high frequency in South China and Southeast Asia including Thailand. Emigrant Chinese population in several countries showed a higher incidence ...
Genetic susceptibility of nasopharyngeal carcinoma

Narisorn Kongruttanachok (Chulalongkorn University, 2001)

Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high rates among Chinese (30-50 per 100,000 people/year). The disease also occurs at moderate frequencies (3-10 per 100,000 ...
Genome wide characterization of unmethylated line-1 MAP : the implication as tumor marker

Chureerat Phokaew (Chulalongkorn University, 2006)

งานนี้เป็นการวิจัยต่อเนื่องจากการผลการศึกษาก่อนหน้าด้วยเทคนิค Combined Bisulfite Restriction Analysis ที่ตำแหน่ง 5’UTR หรือ โปรโมเตอร์ของ LINE-1s (COBRA-L1) ซึ่ง L 1s เป็น active intersperse repetitive retrotransposible ...
Hypomethylation and gene regulation in replicative aging

Wachiraporn Wanichnopparat (Chulalongkorn University, 2012)

Cellular aging are divided to 2 groups, a replicative aging such as fibroblast and a non-replicative aging such as brain. Recently, hypomethylation in aging was reported. In aging cells of PBMC, hypomethylation of Alu and ...
Identification of differentially methylated sequence and gene between white blood cells and sperm

Jiranan Warachit (Chulalongkorn University, 2000)

DNA methylation of cytosine within 5'CpG islands initiated in the germ line effects control of gene expression required for X-chromosome inactivation, genomics imprinting, and cell differentiation for normal embryonic ...
Identification of shared neoantigens in BRCA1-related breast cancer

Lucksica Ruangapirom (Chulalongkorn University, 2021)

Personalized neoantigen-based cancer vaccine has been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and brings about delay in treatment. Using off-the-shelf cancer ...
The possibility of piRNAs sysem to control transposons in cancer cells

Thatchawan Thanasupawat (Chulalongkorn University, 2008)

Down-regulation of Piwil2 (P-element induced wimpy testis like 2) expression induced hypomethylation, the loss of methylation levels, of long interspersed nuclear element-1 (LINE-1 or L1) sequences in the testes of mutant ...
The relationship among DNA methylation, endogenous DNA double strand breaks and genomic instability

Araya Thongnak (Chulalongkorn University, 2011)

Inhibition of DNA-PKcs-mediated non-homologous end joining (NHEJs) under drug- induced histone acetylation reduces cell survival. However the mechanism is not well understood. Recently, we developed a new PCR-based technique ...
Senescent white blood cells in colorectal carcinoma patients

Khin Aye Thin (Chulalongkorn University, 2022)

Colorectal cancer (CRC) and ageing can contribute to changes in immune cells including immuno-senescence. The objectives of the study were to determine if the senescence marker (p16INK4A) was expressed more at higher levels ...
The study of correlation between temperature and endogenous DNA double-strand breaks

Chutipa Phuangphairoj (Chulalongkorn University, 2008)

The aim of this thesis is to evaluate if heat causes DNA double strand breaks (DSBs). There were several studies reported that heat increases of γ-H2AX foci, the serine 139 phosphorylated form of histone H2AX,, one of the ...
A study of line-1 methylation in different types of cancer

Krisanee Chalitchagorn (Chulalongkorn University, 2003)

Genome-wide losses of DNA methylation, global genomic hypomethlation, is a common epigenetic change in malignancies. In mammalian genome, the bulk of cytosine methylation occurs on repetitive element. Long Interspersed ...
A study of tetratricopeptide repeat domain12 (TTC12) methylation in leukemia

Roongtiwa Wattanawaraporn (Chulalongkorn University, 2006)

We searched a candidate tumor suppressor gene of nasopharyngeal carcinoma (NPC) on the critical region of loss of heterozygosity on chromosome 11 q. Unexpectedly, we accidentally discovered that tetratricopeptide repeat ...
The role of b1 methylation, physiologic replication independent endogenous dna double strand breaks (phy-rind-edsb) and laminin 511 e8 proteins in rat second degree burn wound healing

Jiraroch Meevassana (Chulalongkorn University, 2022)

Background: DNA methylation via short interspersed nuclear element (SINE) small interfering (si)RNA prevents DNA damage and promotes cell proliferation. Furthermore, laminin α5 β1 γ1(LM511) is an extracellular structural ...
The T cell senescence in breast cancer

Sikrit Denariyakoon (Chulalongkorn University, 2022)

Background: The cancer-immune cell crosstalk is a common immune-evasion mechanism of cancer. This crosstalk can result in epigenetic changes in immune phenotypes to accelerate tumor growth and metastasis. Senescent T ...
To study the association between methylated endogenous DNA double-strand break and repair pathway

Wanpen Ponyeam (Chulalongkorn University, 2007)

DNA double-strand breaks (DSBs) are the type of DNA damage that is very harmful to cells. This event occurs when both of DNA strands are damaged. Spontaneous DSBs at the background level are called endogenous DSBs (EDSBs). ...

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Browsing Med - Theses by Author "Apiwat Mutirangura"

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