POSTPRANDIAL METABOLIC CHANGE OF THE FIRST HIGH-FAT MEAL WITH AN ISOMALTULOSE-BASED BEVERAGE FOLLOWED BY THE SECOND REGULAR MEAL IN OBESE MEN

Abstract

The consumption of high-fat (HF) diet together with sweet beverage have been increased in modern lifestyle. They associate with increased risks of developing metabolic diseases. Sweetener substitutions are widely used for health benefits. Isomaltulose (ISO), a low-glycemic index sugar, has shown to improve postprandial glycemia. However, no studies have shown the effect of ISO on the second-meal after HF diet. The study aimed to determine the glycemic response, lipid profiles, lipid peroxidation (Malondialdehyde or MDA) and appetite of the ISO-containing beverage together with a HF breakfast followed by a regular lunch in obese men. Twelve healthy obese men, aged between 20-35 years, consumed a HF breakfast with ISO- or Sucrose (SU)-containing beverage in a randomized crossover design. After 4 h, regular lunch was served. Postprandial metabolic parameters and appetite were measured at baseline at 60 min intervals up to 480 min. Compared with SU, consumption of ISO with HF diet significantly decreased on incremental area under the curve (AUCs) of postprandial plasma glucose, insulin and MDA (p<0.05). The incremental AUCs of plasma glucose, triglycerides and non-esterified fatty acids (NEFA) were significantly lower for ISO at post regular lunch (p<0.05). ISO significantly attenuated delay (0-480 min) postprandial plasma glucose and triglyceride incremental AUCs (p<0.05). Moreover, ISO significantly decreased self-reported hunger and increased fullness within whole day (p<0.001). Therefore, the replacing of SU by ISO with HF breakfast appears to control glycemic, lipid profiles and appetite of obese men after consumption of regular lunch and whole day.