Antibacterial and anti-inflammatory biocompatible polymers for wound care

Abstract

The application of a wound care material has been practiced in order to protect the wound from environments as well as to absorb exudate, reduce infections, and reduce inflammation, resulting in the promotion wound healing. In this work, three types of active wound materials are produced. They are silver nanoparticles- embedded poly (vinyl pyiroridone) hydrogels prepared by gamma irradiation synthesis, doxycycline hyclate loaded-poly (acrylic acid) nanofiber mats fabricated by electrospinning technique, and silk sericin-alginate nanoparticles topical gel obtained by emulsification with internal gelation methods. As-loaded silver nanoparticles and doxycycline hyclate are effective broad-spectrum antibacterial agents. While as- loaded silk sericin is natural protein provides antioxidant, anti-wrinkle, cell promotion, and anti-inflammation. Consequently, these as-prepared wound materials possess antibacterial activity or anti-inflammatory properties suitable to use as bio- interactive materials that can facilitate the wound healing process. Physical properties, antibacterial properties, the released characteristic of the active substances, cytotoxicity, in vivo wound healing tests of silver nanoparticles- embedded poly (vinyl pyrroridone) hydrogels, and in vivo anti-inflammatory effect of silk sericin-alginate nanoparticles gel are all evaluated in the current study.