Development of natural rubber matrix using in electrical stimuli transdermal drug delivery application

Abstract

The transdermal drug delivery system (TDDS) is a system to the transport the specific dose of drug into the blood system through the skin. TDDS has been continuously developed and improved for suing with a wide variety of drug molecules. In this work, the influence under effect of the electrical potential and plasticizers were studied for the drug delivery system. Indomethacin (IN), an anti-inflammatory drug. Was used as an inoinc drug model which added in plasticizers to develope the efficient drug transportation. The drug-loaded plasticizer was mixed with natural rubber latex (NR) to prepare a transdermal patch by UV- curing method. The permeation of indomethacin in phosphate-buffered saline (PBS) buffer (pH 7.4) through IN-Ioaded NR film was carried out by a modified Franz diffusion cell at a control temperature at 37 ℃. UV-visible spectrometer was used to dertennine the amount of drug permeation> The results confirmed that an electrical potential and plasticizer can develop the diffusion of drug from a patch through the skin by generating electro-repulsive force.