Factors predicting nutritional scores in HIV-infected elder receiving antiretroviral therapy in Thailand

Abstract

Objectives: (1) To compare means of nutritional scores and means of depression scores from 2016 and 2020 (2) To investigate relationship between nutritional scores and depression scores (3) To establish nutritional score prediction model. Methodology: A longitudinal retrospective survey study was performed. Population were human immunodeficiency virus (HIV)-infected Thai elderly patients aged 50 years and above who were receiving HIV care and had previously participated in the aging cohort study conducted from March 2016 to April 2017 at the HIV-NAT Center, Bangkok, Thailand. Sample size for multiple regression analysis is calculated as 15 cases per 1 independent variable. This study contained 16 variables; then, 240 participants should be included. Purposive sampling method was executed. Results: A total of 250 (100%) participants were included in this study. Most of them were male (60.8%). The mean age was 59.78 ± 5.6 years. The means of nutritional scores declined in 2020 compared to 2016 (24.85 vs 25.78, p < 0.001). The mean depression scores declined in 2020 compared to 2016 (3.14 vs 3.83, p = 0.001). The participants with depression were more likely to be deteriorated in nutritional status over time than those without depression. Nutritional score prediction model confirmed by hierarchical stepwise multiple regression analysis was Nutritional scores =– 0.470 Depression scores** – 0.301 Number of medications** – 0.193 high-density lipoprotein cholesterol (HDL-C) ** + 0.126 triglyceride* + 0.105 CD4* Conclusion: Depression scores, number of medications, HDL-C, triglyceride and CD4 were significant predictors of nutritional scores.