Abstract:
Background: Acemannan, a linear polysaccharide produced by Aloe vera has been shown to have important biological functions promoting wound healing and tissue regeneration. Objective: The aim of this randomized clinical trial was to investigate the impact of acemannan in guided bone regeneration (GBR) with simultaneous implant. Materials and methods: Twenty patients were randomly allocated to test- (Deproteinized bovine bone with Acemannan particulate with mean size of 32.45µm) and control groups (Deproteinized bovine bone only). Twenty implants were placed with simultaneous GBR. CBCT radiographic measurements were conducted immediately and at 3- and 6-months post-surgery. Vertical and horizontal dimensions of the buccal bone were measured at implant platform (0) and at points 2, 4, 6, 8 mm apically. Results: Volumetric reduction of vertical and horizontal buccal bone was significantly smaller in the test group at 3-month post-operation (p<0.05) for every position measured (0, 2, 4, 6, 8), but the difference was not statistically significant at 6 months. Conclusion: Acemannan is a safe and predictable biomaterial, which could potentially enhance short term clinical outcomes of GBR in relation to implant placement. Further studies would be required to document long term efficacy and advantages of its use as a supplement in bone regeneration.
