Synthesis of depsides and their biological activity

Thamolwan Arnanthigo; Napassakorn Chuaycharoen

dc.contributor.advisor	Warinthorn Chavasiri
dc.contributor.author	Thamolwan Arnanthigo
dc.contributor.author	Napassakorn Chuaycharoen
dc.contributor.other	Chulalongkorn University. Faculty of Science
dc.date.accessioned	2022-10-10T06:47:50Z
dc.date.available	2022-10-10T06:47:50Z
dc.date.issued	2020
dc.identifier.uri	http://cuir.car.chula.ac.th/handle/123456789/80631
dc.description	In Partial Fulfillment for the Degree of Bachelor of Science Department of Chemistry, Faculty of Science Chulalongkorn University Academic Year 2020	en_US
dc.description.abstract	Synthesized depsides were modified based on the core structure of jaboticabin, to enhance its biological activities. Desired depsides were synthesized through an esterification with methyl 2-(2- hydroxyphenyl) acetate (NT0) and a carboxylic acid compound. DCC and DMAP were required to activate the carboxylic group and solvent used was DCM. 2-(2-Methoxy-2-oxoethyl)phenyl 3- nitrobenzoate (NT1) and 2-(2-methoxy-2-oxoethyl)phenyl (E)-3-(2,6-dichlorophenyl)acrylate (NT18) showed powerful anti ɑ-glucosidase activity with an IC50 value of 68.7 μM and 84.8 μM. The IC50 values obtained from assay were lower than that of Acarbose, the standard reference (IC50 = 93.6 μM). On the other hand, none of the compounds showed good potential towards antioxidant activities.	en_US
dc.language.iso	en	en_US
dc.publisher	Chulalongkorn University	en_US
dc.rights	Chulalongkorn University	en_US
dc.subject	Depsides -- Synthesis	en_US
dc.subject	Antioxidants -- Synthesis -- Inhibitors	en_US
dc.title	Synthesis of depsides and their biological activity	en_US
dc.type	Senior Project	en_US
dc.degree.grantor	Chulalongkorn University	en_US