Green synthesis of gold nanoparticles using natal lily crinum moorei extract and biological activities

Abstract

Crinum moorei as medical herb has different pharmacological activities such as anti-cancer and anti-inflammatory properties. Gold nanoparticle (AuNP) is an interesting anti-cancer drug carrier which can solve anti-cancer drug’s problems with good biocompatibility, non-toxicity and suitable size for the intracellular uptake to treat to the target cells. From the beginning, other reducing agents were used to synthesize AuNPs. However, they lead to the contamination of chemicals on AuNP’s surfaces which limits the medical application or long process and time consuming. Therefore, plant extracts were studied to make a remarkable dual function: the synthesized AuNPs agent and drug agent. In this research, AuNPs were prepared by using Crinum moorei extract as a reducing and stabilizing agent in one-pot synthesis, and their biological activities were evaluated. The synthesized AuNPs, HAuCl4 and Crinum moorei extract was optimized and characterized by Ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy, Dynamic light scattering and Transmission electron microscopy. The results from UV-Vis spectroscopy show surface plasmon resonance band (SPR) around 530 nm and TEM image show spherical shape with the particle size 7-9 nm. Furthermore, the synthesized AuNPs were also evaluated their anti-cancer and anti-inflammatory activities.