Effects of tetrachlordecaoxide (TCDO) in norepinephrine-induced acute renal failure in dogs

Abstract

This investigation was performed to study the effect of tetrachlor-decaoxide (TCDO) on general circulation and renal function of norepinephrine- induced acute renal failure animals. Experiments were carried out on sixteen anesthetized male dogs. Animals were divided into 4 groups for four dogs in each group. Each dog received intravenous infusion of norepinephrine (NE) 0.75 ug/kg.bw./min at the rate of 1 ml/min for 40 minutes. During NE infusion, there was a significant increase in mean arterial blood pressure (MAP), while heart rate (HR) decreased. After that in the control group, MAP reduced to normal level but it showed significant increase of HR more than the control value. When administered of TCDO 0.005 and 0.01 mg/kg.bw. in group II and group III, respectively, the changes of general circulation were not significantly different from the control group. In group IV which infused fourose-mide 10 mg/kg.bw. intravenously, the MAP and HR were found to return to control value after NE infusion. After NE infusion, it was no flow of urine significant decrement of GFR, ERPF and ERBF. During 4 hours after NE infusion there were no significant difference of the increments of GFR, ERPF, ERBF and renal vascular resistance (RVR) from the control group whereas the urinary excretion of sodium, potassium and chloride ions slightly increased when those compared to the control group. In comparison to the effect of furosemide which could inhibit the effect of norepinephrine on renal functions, but not for the action of TCDO. However, changes of renal metabolism were affected by the action of TCDO which were not apparent in furosemide treated animals.