Development of tablet manufacture method of ergoloid mesylate by solid dispersions

Abstract

The dissolution characteristics of ergoloid mesylate from its coevaporates using PEG 4000, PEG 6000, PVP K-30, PVP K-90, poloxamer 188 and a mixture of 3% poloxamer 188 in PVP K-30 as a carriers were investigated. The solid dispersions of drug and carriers were prepared in the ratio of 1:1, 1:3, 1:5, 1:7. A dramatic increase in the dissolution rate of ergoloid mesylate was attained as compared with pure drug and corresponding physical mixtures. Poloxzmer systems produced the fastest dissolution rate of the drug. The dissolution rate of the drug increased as the ratio of carrier to drug was increased. Drug-PVP coevaporates dissolved at a faster rate than did drug-PEG systems. The release of ergoloid mesylate slightly increased as the molecular weight of PVP and PEG decreased. The combination of PVP K-30 and 3% poloxamer 188 as carriers yielded more rapid dissolution of ergoloid mesylate than PVP K-30 alone. Solid dispersions of PVP K-30 and poloxamer 188 systems were used to manufacture tablets by direct compression method. The tablets of this type exhibited faster dissolution rate of the drug when compared with the tablets prepared by conventional direct compression and wet granulation methods.