Effects of omeprazole on acid excretion in the kidneys of hypokalemic dogs

Abstract

This experiments were performed to study the effects of omeprazole on acid excretion in the kidneys of hypokalemic dogs. The relationship of the mechamisms of renal hydrogen ion secretion and potassium ion reabsorption by the activity of H-K ATPase was also carried out. The results of experiments in animals pretreated with acute furosemide infusion (group 1), prolonged furosemide administration (group 2), and insulin infusion group (group 3) showed a marked decrease in plasma potassium concentration. The animals in group 1 pretreated with furosemide caused an increase in urinary titratable acid (U[subscript TA]V) and ammonium (U[subscript NH₃]V) excretion while it was not apparent in group 2 and group 3. Urinary potassium excretion (U[subscript K]V) in group 1 and group 2 was shown to increase. In group 3, animal given insulin did not alter U[subscript K]V. After omeprazole injection, U[subscript K]V, U[subscript TA]V, and U[subscript NH₃]V of all groups did not show a significant changes. During experiments, omeprazole did not affect to either general circulation or renal hemodynamics in all groups. These results indicate that omeprazole has no effect on acid excretion and potassium reabsorption in the kidneys of hypokalemic dogs without correlation to the activity of H-K ATPase. Many factors are expected to involve the activity of omeprazole including urinary acidification, the pH of renal tubular cell, the dosage of omeprazole using during experiments and the quantity of K⁺ delivery in the distal nephron.