Comparative study between vitamin B 1-6-12 and vitamin B 12 for neurosensory recovery after bilateral sagittal split ramus osteotomy

Abstract

A major complication from Bilateral Sagittal Split Ramus Osteotomy (BSSRO) is inferior alveolar nerve injured that manifest as neurosensory disturbance (NSD) on the lower lip, chin. Although the NSD is not a life-threatening problem but it impacts the patient's daily life. Vitamin B is commonly used to treat peripheral neuropathy but it is only few study for NSD from BSSRO. The aim of this study was to evaluate the effect of oral vitamin B1-6-12 and vitamin B12 on NSD after BSSRO. The study design was as a randomized, single blinded control trial of 75 patients who were NSD from BSSRO (n=25). The first group was vitamin B1-6-12 group that taking 1 tablet 3 times daily. The second group was vitamin B12 group that taking 1 tablet 3 times daily. The third group was the control group without taking vitamin B. Clinical Neurosensory Testing (CNT) was performed with static two-point discrimination, moving two-point discrimination, light touch and pinprick at preoperation, immediate, 1 week, 1 month, 3 months and 6 months and converted to Global Sensitivity Score (GSS). GSS was calculated to recovery proportion and was analysed with Friedman test and post hoc analysis with Wilcoxon signed rank test for intragroup comparison on the passing time and Kruskal Wallis H test and post hoc with Mann Whitney U test were used for intergroup comparison. Results showed significantly increasing recovery improvement in all groups on the passing time (p<0.05). Vitamin B1-6-12 orally were significantly highest recovery proportion when comparing with and control vitamin B12 at 6 months (p=0.038, p=0.033).