Synthesis of phenoxyacetic acid and related compounds as plant growth regulators

Abstract

The methodology for the preparation of acid chlorides under mild conditions was thoroughly carried out. Acid chloride was prepared by treating carboxylic acids with CL₃CCN and PPh₃, after that it was transformed into amide by trapping with amine. The optimized conditions including the mole ration of CL₃CCN and PPh₃, reaction time, temperature, solvent system and of chlorinated reagent were investigated. Various carboxylic acids and amines were examined to verify this developed procedure. It was found that this method was more suitable with aromatic carboxylic acids than aliphatic acids and more appropriate with acid with electron-donating group than acid with electron-withdrawing group. Moreover, this method could also be applied for the synthesis of eleven biologically active amides.