Molecular design and synthesis of external stimuli responsive structure under self-assembly systems

Abstract

The present work focuses on the molecular self-assembly of host-guest system and polymeric chain. In the first part, the conjugation of the chemiluminescent molecules, luminol, onto N,N-bis(5-methyl-2-hydroxybenzyl) methylamine by diazotization reaction to obtain novel host compound is proposed. The metal ion guest entrapped in host allows the flow injection analysis system being possible to use in a single system where the chelating agent is not required. In the second part, RAFT technique was applied for preparing a copolymer with a controlled structure in micelle and vesicles form. The work originally proposes a multi-responsive micelle by designing a copolymer with a thermoresponsive of poly(N-isopropylacrylamide), PNIPAAM, a pH sensitive chain of poly(2-(dimethylamino)ethyl acrylate), PDMAEA, and a fluorescence sensitive chain of poly(N-vinylcarbazole), PNVC. The work further shows a simple approach to control morphology of the copolymer containing PNIPAAM and PDMAEA to obtain micelle or vesicles. The work also demonstrates a simple control pH of together with copolymer ratio to obtain a fluorescent vesicle and micelle system of which can be formed selectively. Finally, the mixed micelle systems from chitosan and multi responsive fluorescent micelle were reported.