The study of tablet disintegrating properties of durian rind extracts

Abstract

Durian rind extract from alcohol (D1) and acid –alcohol extraction (D2) were studied for their disintegration properties in comparison with commonly used disintegrants like Ac-di-Sol(R), corn starch, Explotab(R), Kollidon CL(R), Nymcel(R) and Starch 1500(R). Physical properties of disintegrants such as hydration capacity, swelling, water penetration, action on the disintegration time of tablets containing water soluble (α -lactose monohydrate) and water insoluble (dibasic calcium phosphate dihydrate) diluents compressed at three different compressional forces (500, 1000 and 1500 kg) were evaluated. In addition, the abilities to improve the dissolution rate of hydrochlorothiazide and pyridoxine hydrochloride in water insoluble diluent were also determined. The results clearly showed that both forms of durian rind extract appeared to be an effective disintegrating agent in directly compressed tablets made with either diluent and exhibited superior disintegrating properties than corn starch and Starch 1500(R) at quite low concentration. However, these properties were in than those superdisintegrants such as Ac-di-Sol(R), Explotab(R), Kollidon(R), and Nymcel(R).