Effects of varoius types of milk, soymilk and other factors on the qualities of baked custard

Abstract

Famotidine solid dispersions were prepared by melting and solvent methods in mannitol, glucose, sorbitol, xylitol, PEG 6000, citric acid anhydrous, PVP 12 PF, 1:1 mannitol-PEG 6000 and 1:1 mannitol PVP 12 PF. Stickiness and hygroscopicity occurred in all dispersions prepared by the solvent method. Only the dispersions prepared by the melting method in mannitol, sorbitol and xylitol were selected for solubility study since they were dry easily and possessed good appearance after dried. A dramatic increase in the solubility of famotidine was attained as compared with pure drug and corresponding physical mixtures. Dispersion of 1:10 famotidine mannitol produced the greatest solubility enhancement (260%), followed by the dispersions of sorbitol (54%) and xylitol (25%) when prepared at the same drug carrier ratio. The solubility increased was not linear with the increase in carrier concentrations. Dissolution profiles of tablets prepared by 1:10 famotidine solid dispersions was higher than the three commercial tablets followed by tablets from physical mixture which exhibited higher dissolution rate than the pure drug alone, all of which were in the USP requirement. To increase in aqueous solubility and to avoid instability of famotidine in acidic solution could be achieved by the process of lyophilization. From the stability test, the lyophilized product kept as dry powder form for three months at 45°c, 75% RH had the percentage content remains in the range of 92-100. The physical and chemical stability test of the reconstituted solution of famotidine by accelerated method and at room temperature condition indicated that the formulation produced in acetate buffer exhibited the longer shelf-life than the formulation produced in L-aspartic acid.