Sustained release theophlline tablets prepared from theophylline granules coated with ethylcellulose

Abstract

Theophylline granules coated with ethylcellulose were prepared using fluidized bed technique. Sustained release characteristics of the coated granules and the tablets prepared from coated granules were evaluated. The release rate of the drug from the coated granules and the tablets decreased when increasing the amount of ethylcellulose coating. Type of fillers employed in preparing of the theophylline granule were found to have the effect on drug release. Incorporation of disintegrant in the tablet formulation produced the faster drug dissolution. Unpredictable alteration of release profiles were observed when varying the compressional force used in tableting process.