Detection of antibodies specific to mosquito cells in human and animal serum

Abstract

Most of the studied are focused on reaction of host to mosquito’s saliva proteins. In this study, the host immune response to mosquito cells have been studied by developing methods for analyzing host response to mosquito cell and immune response in experimental animal. The sources of antigens that elicit antibodies could be from cells in saliva during mosquito bite. The antibodies response to mosquito cells proteins can be detected in human serum as in the experimental animal. The antibodies level is higher in groups that have high exposure to mosquito bite such as guards. The antibodies can not be detected in cord blood indicated that there is no passive transfer of maternal antibodies. These antibodies can not be detected or can found with low level in serum of patient with dengue infection. The mosquito’s membrane proteins should present in the dengue virus envelope during replication cycle in mosquitoes. Thus the mosquito antibodies present in host might modified the outcome of infection and may be one of the host factors that protect human against dengue infection or implicate in pathogenesis of dengue fever. And this might be the new strategy for vaccine development against the dengue virus infection in the future.